HLA tetramers, also known as MHC tetramers, are the gold standard for precise detection of CD8+ antigen-specific T cells. Widely used in the development of anti-cancer and antiviral immunotherapies, they enable detailed analysis of immune responses.
- Explore our selection of HLA tetramers at www.tetramerstore.com
HLA refers to human leukocyte antigen, part of the MHC gene complex in humans, which presents peptides from pathogens and self-antigens on cell surfaces. These peptides, in combination with HLA, are surveilled by T cells via their T cell receptors. If recognized as foreign, these cells are targeted for destruction by the immune system.
Recombinant HLA tetramers, linked to peptide antigens and fluorochrome-conjugated streptavidin, are used to detect antigen-specific T cells via flow cytometry.
However, conventional HLA tetramers are often unstable, inflexible, expensive, and involve lengthy delivery times.
To overcome these issues, Tetramer Store has developed a revolutionary form of empty HLA tetramers, offering unmatched stability and versatility.
We provide the widest selection of HLA tetramers with fast delivery, and our cutting-edge HLA tetramer technology was recently featured in Science Immunology.
Key Applications:
- Conventional HLA tetramer staining for standard assays
- Investigating T cell reactivity to neoantigens
- Examining proprietary peptide antigens without disclosure
- Multi-color flow cytometry for detecting multiple T cell specificities
Key Benefits:
- Off-the-shelf HLA tetramers with over 300 specificities available
- Global shipping within 24 hours of ordering
- Custom HLA tetramers designed with your peptide, delivered in 3 weeks
- Brighter staining due to proprietary stabilized HLA complexes
- Freeze-compatible formulation for flexible aliquoting and storage
- Wide range of fluorochrome colors, with custom colors available on request
We offer a broad range of colors including PE, BV421, BUV395, APC-Cy™7, APC, BV510, BV480, PE-Cy™5, PE-CF594, PE-Cy™7, PerCP-Cy™5.5, PerCP, FITC, BV605, BV650, BV786, APC-R700, BB515 and BUV737.