MHC Tetramer

MHC Tetramers from Tetramer Store: Cutting-Edge Precision and Flexibility for T Cell Detection

Tetramer Store has pioneered a highly stable and innovative form of MHC Tetramers (also known as HLA Tetramers), offering unparalleled precision in detecting and characterizing antigen-specific T cells. Our proprietary MHC tetramer technology, recently featured in Science Immunology, provides faster delivery and a wide range of color options, supporting multiple research applications.

[Order MHC Tetramers from Tetramer Store here]

Innovative Empty Loadable MHC Tetramers

In addition to our conventional MHC Tetramers, we offer Empty Loadable MHC Tetramers, a groundbreaking solution that allows you to instantly load peptide antigens for on-demand tetramer assays. These “DIY Tetramers” provide unmatched flexibility and ease of use for rapid staining and characterization of T cells.

Key Applications:

  • Conventional MHC Tetramer staining for standard protocols
  • Exploring T cell responses to neoantigens
  • Investigating proprietary peptide antigens
  • Multi-color flow cytometry for multiple T cell specificities

Key Benefits – Speed and Flexibility:

  • Off-the-shelf MHC Tetramers with over 300 specificities, ready to ship within 24 hours
  • Custom Tetramers tailored to your specifications, shipped within 3 weeks
  • Brighter staining due to a stabilized MHC complex
  • Freeze-compatible formulation for aliquoting and freezing
  • A wide range of colors, with custom colors available upon request

Empty Loadable MHC Tetramers: Unmatched Antigen Flexibility

Empty Loadable MHC Tetramers offer extraordinary flexibility in tetramer assays. Simply add your peptide antigen, incubate, and stain your sample—no UV cleavage or peptide exchange required. This capability significantly reduces the cost and time associated with tetramer assays, especially when screening for multiple T cell specificities in neoantigen research or proprietary peptide antigens.

Advantages of Tetramer Staining Assays

  • Enables isolation and characterization of antigen-specific T cells via fluorescence-activated cell sorting (FACS)
  • Short assay time and easy-to-use protocols
  • Applicable for both mouse models and human immune studies
  • Ideal for multi-color flow cytometry or combinatorial encoding, allowing for simultaneous analysis of multiple T cell populations in one sample

Revolutionizing Immunotherapeutic Development

MHC tetramer technology has transformed cancer immunotherapy and vaccine development, providing unprecedented accuracy in detecting and isolating antigen-specific T cells. This facilitates:

  • Monitoring immune responses and disease progression
  • Isolating and expanding disease-specific T cells for ex vivo proliferation
  • Reintroducing expanded T cells into patients for targeted immune system enhancement

Our MHC Tetramers enable precise, high-resolution analysis of immune responses, essential for the development of immunotherapies, vaccines, and advanced T cell research.

Start enhancing your T cell research with MHC Tetramers from Tetramer Store today.

Tetramer Specifications

Tetramer Store supply MHC Tetramers in various test sizes and the colors PE, BV421, BUV395, APC-Cy™7, APC, BV510, BV480, PE-Cy™5, PE-CF594, PE-Cy™7, PerCP-Cy™5.5, PerCP, FITC, BV605, BV650, BV786, APC-R700, BB515 and BUV737. For other colors, please enquire.