MHC monomer biotinylated

MHC Monomers from Tetramer Store: Versatile Tools for Immunological Research

Tetramer Store’s Class I MHC Monomers offer researchers highly flexible tools for a wide range of immunological applications. Our monomers are biotin-labeled, making them ideal for use in specialized immunoassays, both in solid and solution-based formats. These reagents can be used to measure interactions between peptide-MHC (pMHC) complexes and monoclonal antibodies, recombinant T cell receptors (TCRs), or other pMHC-binding molecules. This makes them highly useful for screening antigen-specific CAR T cell receptors and other immunotherapies.

Stabilized Empty MHC Complexes: Flexibility and Efficiency

Our proprietary stabilized empty MHC monomers represent a significant advancement in flexibility and efficiency for rapid screening of multiple pMHC specificities. Researchers can easily load these monomers with a wide variety of peptides, enabling quick and efficient experiments in T cell immunology, antigen-specific CAR T development, and immune profiling.

Applications of Biotinylated MHC Monomers

MHC monomers from Tetramer Store are designed for numerous cutting-edge applications, including:

  • Single Cell TCR Immune Profiling: Use MHC monomers in workflows to identify and characterize T cell receptor (TCR) specificities at the single-cell level, providing insights into immune responses.
  • Customizable MHC Tetramers: Create specialized MHC tetramers with alternative labels, such as DNA-barcoded or metal-labeled MHC tetramers, to tailor detection to your specific needs.
  • Antigen Fishing: Employ empty MHC monomers for antigen fishing assays, where the monomers are loaded with antigen and coupled with mass spectrometry (MS) to detect antigen-specific immune responses.
  • Plate or Chip Coating for Assays: Biotinylated MHC monomers can be used to coat plates or chips, enabling high-throughput screening of pMHC specificity in assays.
  • Microfluidics-Based T Cell Assays: MHC monomers are compatible with microfluidic systems for T cell assays, facilitating rapid, small-scale testing and analysis.
  • Immunization Studies: These monomers can also be employed in immunization protocols to raise TCR-like antibodies, expanding their utility in vaccine development and antibody research.

Why Choose Tetramer Store’s MHC Monomers?

  • High Stability: Our MHC monomers are stabilized for optimal performance, ensuring reliable and reproducible results in every experiment.
  • Customizable Flexibility: Load with your peptide of choice to screen multiple specificities, providing a versatile tool for research in immunotherapy, vaccine development, and more.
  • Biotin Labeling for Versatile Use: The biotinylation of our MHC monomers allows for easy adaptation to various assays, such as solid-phase, solution-phase, or microfluidic systems.

Ordering MHC Monomers

Browse our webshop for a selection of biotinylated MHC monomers. We offer rapid worldwide shipping and custom options to meet your research requirements. Whether for basic research, drug development, or cutting-edge immunotherapy research, Tetramer Store’s MHC monomers offer the precision and flexibility you need.