PE and APC-Conjugated Streptavidin-Dextran MHC Multimers
Our PE and APC-conjugated Streptavidin-Dextran MHC Multimers are designed for researchers studying antigen-specific T cell populations.
Based on a high-molecular-weight dextran scaffold, these reagents support multivalent antigen presentation and can be used in live-cell flow cytometry
and single-cell immune profiling.
Key Characteristics
- Hydrophilic Dextran Scaffold: Built on a 500 kDa amino dextran backbone to support flexible and efficient presentation of peptide-MHC complexes.
- Multivalency and Bright Fluorescence: Each dextran molecule carries 4 streptavidin molecules and either 3 PE or 6 APC fluorophores to facilitate bright and sensitive detection of T cells.
- Optional Customization: The scaffold can accommodate up to ~10 biotinylated molecules, which enables flexible assay design using additional biotin-tagged components.
- Compatibility: Suitable for live-cell staining, flow cytometry, and workflows requiring modular conjugation strategies.
Application Flexibility
These multimers are compatible with advanced workflows including high-dimensional phenotyping and integration with sequencing platforms that utilize biotinylated tags.
For example, users may explore protocols incorporating DNA-barcoded detection reagents.
Note: Some applications involving barcoded DNA oligonucleotides may be subject to third-party intellectual property rights. Users are responsible for ensuring freedom to operate for their intended use.
Technical Specifications
- Backbone: 500 kDa amino dextran
- Streptavidin per Dextran: 4
- Fluorophores per Dextran: 3 PE or 6 APC
- Typical Biotin-Binding Sites: ~10
- Applications: Flow cytometry and T cell detection assays; potential compatibility with barcoded single-cell approaches
Contact Us
For detailed specifications, technical guidance, or to request a quote, please
contact us here.